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varsel.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"4","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Forskjellige administrasjonstidspunkt","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph"}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden benyttes når rekvirent mener at begge behandlinger skal bestå på grunn av at de har forskjellige administrasjonstidspunkt.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"5","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Forskjellige legemiddelegenskaper","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph"}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph"}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden benyttes når formulering mellom to legemidler det varsles på er forskjellig og at behandlingene skal bestå.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"6","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Klinisk nødvendig kombinasjon","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph"}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden benyttes når varsel overstyres og begge legemiddelbehandlinger er nødvendig.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"7","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Har informert pasient om mulige bivirkninger","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden benyttes når rekvirent velger å informere pasient om problemstilling. Er en form for selvmonitorering.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"8","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Ikke relevant","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden benyttes når varsel er et resultat av overvarsling på grunn av mangler i varslingfunksjonalitet.","type":"text"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[80.0]},"content":[{"type":"paragraph","content":[{"text":"9","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"Annet","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[174.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[172.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[178.0]},"content":[{"type":"paragraph","content":[{"text":"Ja","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[561.0]},"content":[{"type":"paragraph","content":[{"text":"Koden annet benyttes når ingen andre koder passer. Det stilles krav til tekstlig dokumentasjon i tillegg.","type":"text"}]}]}]}]},{"type":"paragraph","content":[{"type":"hardBreak"}]},{"type":"heading","attrs":{"level":1},"content":[{"text":"Eksempler","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Eksempel VarselHandtert - interaksjon","type":"text"}]},{"type":"paragraph","content":[{"text":"Eksemplet er generert i XML SPY, håndkodet og viser delstruktur i meldingsutvidelsen.","type":"text"}]},{"type":"codeBlock","attrs":{"language":"xml"},"content":[{"text":"\n\n\n\t--guid--\n\t\n\t--guid--\n\t\n\tDette går bra\n\t2001-12-17T09:30:47Z\n\t\n\t\t\n\t\t\t01234567\n\t\t\tFast\n\t\t\tLege\n\t\t\n\t\t\n\t\t\t877866\n\t\t\tMitt legekontor\n\t\t\n\t\n\t\n\t\tID_162391B4-3B02-4327-B00F-9F8F00E63D94\" \n\t\thttp://www.kith.no/xmlstds/eresept/m30/2014-12-01\n\t\t\"Økt konsentrasjon av ketokonazol (gjennomsnittlig 2-3 ganger i interaksjonsstudier). Også konsentasjonen av ritonavir, men kanskje fremfor alt de midlene som brukes sammen med ritonavir i faste kombinasjoner, kan øke (rundt en fordobling av konsetrasjonen av paritaprevir, mindre økning for dasabuvir, ingen økning for ombitasvir).\"\n \n ","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Eksempel på FEST oppføring for interaksjon","type":"text"}]},{"type":"codeBlock","content":[{"text":"\n\n\tID_2156BEAC-024C-4909-B82D-3F47BCE9588D\n\t2020-06-10T00:53:22\n\t\n\t\n\t\tID_162391B4-3B02-4327-B00F-9F8F00E63D94\n\t\t\n\t\tØkt konsentrasjon av ketokonazol (gjennomsnittlig 2-3 ganger i interaksjonsstudier). Også konsentasjonen av ritonavir, men kanskje fremfor alt de midlene som brukes sammen med ritonavir i faste kombinasjoner, kan øke (rundt en fordobling av konsetrasjonen av paritaprevir, mindre økning for dasabuvir, ingen økning for ombitasvir).\n\t\tRitonavir hemmer metabolismen av ketkonazol via CYP3A4. Ketokonazol kan øke konsentrasjonen av anti-HIV-midlene.\n\t\t\n\t\tDosetilpasning: Dosebehovet av ketokonazol vil anslagsvis være 50-70% lavere i kombinasjon med ritonavir. Dosereduksjonen av anti-HIV-midlet vanskeliggjøres hvis det brukes faste kombinasjoner, siden økningen av konsentrasjonen av de ulike komponentene som inngår ikke er like stor for alle. Derfor vil det være enklere å unngå kombinasjonen enn å dosejustere. Produsenten av preparatet Viekirax kontraindiserer samtidig bruk pga. uforutsigbar effekt.\nLegemiddelalternativer: Ingen åpenbare. Må vurderes på individuelt grunnlag.\n\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\tKaeser B, et al. Drug-drug interaction study of ketoconazole and ritonavir-boosted saquinavir. Antimicrob Agents Chemother 2009;53(2):609-14.\n\t\t\t\n\t\t\n\t\t\n\t\t\tSekar VJ, et al. Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers. Br J Clin Pharmacol 2008;66(2):215-21.\n\t\t\t\n\t\t\n\t\t\n\t\t\tSPC Viekirax\n\t\t\t\n\t\t\n\t\t\n\t\t\t\n\t\t\t\tKetokonazol\n\t\t\t\t\n\t\t\t\n\t\t\n\t\t\n\t\t\tRitonavir\n\t\t\t\n\t\t\t\tRitonavir\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\tDasabuvir, ombitasvir, paritaprevir og ritonavir\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\tOmbitasvir, paritaprevir og ritonavir\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\tLopinavir og ritonavir\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\tDarunavir og ritonavir\n\t\t\t\t\n\t\t\t\n\t\t\n\t\n","type":"text"}]}],"version":1}